A recent review that delves into the collaborative interplay of different marijuana chemical compounds, such as flavonoids, terpenes and cannabinoids, has shown that to fully understand the therapeutic potential of marijuana, it’s important to understand how the different constituents interact. Echoing sentiments expressed in the cannabis community for years, the study underscores that the effects of cannabis extend beyond only CBD and THC.
The study stresses the entourage effect, which describes the complex interactions between flavonoids, terpenes, cannabinoids and other chemicals found in marijuana plants. The study, published in the scientific journal “Molecules” last month, highlights the need to explore these complex connections to fully realize cannabis’ therapeutic potential in the field of natural plant medicine.
The study recommends a more thorough investigation of the precise ratios of flavonoids, terpenes and cannabinoids in various marijuana products or strains. It implies that this kind of examination can result in the creation of more specialized and efficient medical treatments.
Terpenes and cannabinoids interact with the body’s endocannabinoid system to produce a range of effects, including neuroprotective, anti-inflammatory and analgesic properties. However, research indicates that other substances in the plant may also have an impact on their effects, which may not be entirely attributable to their separate actions.
The research notes that terpenes, for instance, have demonstrated pharmacological properties and can interact with neurotransmitter receptors and enzymes, potentially modulating the effects of cannabinoids. Further, the entourage effect proposes that terpenes and cannabinoids working together could have a therapeutic benefit that is more potent than the sum of their separate actions.
The authors also cited studies that suggest that flavonoids may have neuroprotective, antioxidant, and anti-inflammatory qualities with cannflavins, a type of flavonoid, showing strong anti-inflammatory properties, especially against neuroinflammation. The study ALSO sheds light on the intricate network of chemical interactions that could influence the effects of cannabis on individuals.
However, the authors stress the need for further research to elucidate the underlying mechanisms and synergistic effects of flavonoids, terpenes and cannabinoids. They further highlight the importance of exploring the biotechnological, bioactivities and biosynthesis applications of these compounds to harness their potential and expand treatment options.
The study also notes that the regulatory obstacles to marijuana research present serious difficulties. It highlights how important it is to resolve these barriers, especially those resulting from marijuana’s Schedule I status, to enable more widespread access to marijuana products for research.
Companies such as Tilray Brands Inc. (NASDAQ: TLRY) (TSX: TLRY) may be doing a lot behind the scenes to leverage the therapeutic effects of combining different components of marijuana plants.
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